I kept waiting for Merlin to chime in! (try his test,rub a mouse on your hand & see how much love a reptile has for it's food!) it's all about respect & knowledge! I would love for my snakes to love me back! as far as domesticated, I can take a bone and play with my lab,or stick my hand in her food bowl while she eats! I would not offer my BP a rodent by holding it in the palm of my hand!