Hello all! I'm new to HC, and breeding mice. I have a question on breeding mice. I'm planning to get 1 male and 4 females. Once a colony is established, is it critical to bring in new blood for breeding? Unsure (and can't find anything) on inbreeding mice, it seems logical that I'd need to continuously make sure I buy new breeders, but I really just don't know. Would it hurt to inbreed mice? Hope someone here could help.